
The final pair of unbeaten teams in the NFL saw their perfect records shattered during the fifth week as both the Philadelphia Eagles and Buffalo Bills suffered shocking home defeats.
Denver's football team transformed from dark horses to headline-makers following an impressive rallying win against the reigning Super Bowl champions Philadelphia, prior to boarding a flight for Sunday's overseas matchup.
New England's squad then visited Buffalo and halted Buffalo's undefeated start with a statement win of their own in their first national television appearance in a full year.
The Baltimore Ravens experienced a third consecutive loss - their defensive woes could be terminal for their play-off hopes - while the Dallas Cowboys, Indianapolis Colts, and Detroit Lions celebrated decisive victories on another eventful Sunday.
Not only was it defeating the Super Bowl champions, but the manner of their 14-point comeback that made Denver's win by 21-17 in Philadelphia such a signature success.
Philadelphia had secured 10 contests consecutively, 12 in a row on home turf and 20 of their last 21 total before Broncos quarterback Bo Nix engineered two touchdowns in five fourth-quarter minutes and a late field goal.
Philadelphia are now 4-1 but there is a big worry about the offence, which sits among one of the worst in the NFL. Wideout DaVonta Smith says they are not "on the same page" with quarterback Jalen Hurts.
The Broncos' defensive unit, which tackled Hurts on six occasions, had much to contribute with the outcome, and, combined with an established starting QB in Nix and top head coach in Sean Payton, they possess all the components to launch a legitimate playoff push.
The Broncos meet New York's Jets at Tottenham Hotspur Stadium on Sunday.
Should the Broncos' victory was somewhat anticipated, nobody saw New England traveling to Buffalo and beating Josh Allen's Bills, but they accomplished it with tremendous resilience.
Their initial national television appearance for Drake Maye produced a star-making showing as he led a decisive scoring drive in the final moments to secure victory 23-20.
The young QB was tough and executed accurate passes at the right times, several to former Bills receiver Stefon Diggs, who delivered a big game for Mike Vrabel's side.
Vrabel was anticipated to improve the situation in New England, but a win like this came earlier than many predicted.

New England's defensive squad contained the Buffalo Bills attack during their surprising away win.
The season is turning into a nightmare for the Ravens, who were missing a host of defensive stars as they were hammered 44-10 by Houston's team.
It equaled their biggest loss at home, and falling to 1-4 for this year means one of the preseason Super Bowl contenders have just a small chance of reaching the play-offs.
The Ravens are now 4-11 when missing star QB Lamar Jackson, who was injured, but it is an exceptionally poor defensive unit that is the real problem - for a team that have been synonymous with stout defense historically.
Houston strolled to the win as Baltimore became the first team in modern NFL history to concede at least 37 points in four of their first five games. Their campaign is already in tatters.
The Lions' running back duo Jahmyr Gibbs and David Montgomery scored a touchdown in the same game for the fourteenth occasion - a joint NFL mark - as the Lions put away Cincinnati 37-24.
The win made it four wins in a row for the league's top scorers Detroit, but not one against opponents with positive records.
A more surprising 4-1 side are Indianapolis. With their star running back running in three touchdowns in their 40-6 hammering of Las Vegas and quarterback Daniel Jones looking like a new man, they will be a tough match for any side.
Tampa Bay entered the four-win group with a mesmeric 38-35 victory in Seattle in which the sides traded nine touchdowns in 10 sparkling possessions before the Seahawks cracked first with a late turnover.
The kicker kicked the game-winner with the last kick of the contest for the second time this season. Each of the Bucs' wins have been secured in the last minute.
Given how New Orleans and Tennessee Titans began the season, they required assistance to get their initial victories, and they received ample due to several comical mistakes from the New York Giants and Arizona Cardinals.
Following a strong opening from New York rookie Jaxson Dart, New York committed five turnovers - one was decisively taken back for six points - while also allowing Rashid Shaheed to find the end zone on a long catch and run as the Saints prevailed 26-14.
Arizona were more disastrous as they blew a 21-3 lead primarily due to two massive blunders.
First, Emari Demercado inexplicably dropped the ball just before crossing the line for a long touchdown.
Worse was to come when the Cardinals picked off Cam Ward near their own goal line, then lost the football into the end zone for Tyler Lockett to score as the Titans snapped a ten-contest losing streak with a narrow win.

The receiver scored among the most bizarre touchdowns witnessed this season.
This left New York's Jets as the sole victory-less team remaining in the league after their bruising 37-22 defeat by the Cowboys.
The quarterback became the first player in NFL history to surpass 4,000 passing yards and 1,000 yards rushing in his initial twenty career games as he came back from being hurt to guide Washington to a notable 27-10 victory at the Los Angeles Chargers.
Rico Dowdle was the standout performer for the Carolina Panthers with 206 rushing yards in their exciting 27-24 win over Miami.
Minnesota Vikings 21-17 Cleveland Browns
Houston Texans 44-10 Baltimore Ravens
Miami Dolphins 24-27 Carolina Panthers
Las Vegas Raiders 6-40 Indianapolis Colts
New York Giants 14-26 New Orleans Saints
Dallas Cowboys 37-22 New York Jets
Denver Broncos 21-17 Philadelphia Eagles
Tennessee Titans 22-21 Arizona Cardinals
Tampa Bay Buccaneers 38-35 Seattle Seahawks
Detroit Lions 37-24 Cincinnati Bengals
Washington Commanders 27-10 Los Angeles Chargers
New England Patriots 23-20 Buffalo Bills
San Francisco 49ers 26-23 Los Angeles Rams (OT)
An avid hiker and travel writer with a passion for exploring Italy's hidden trails and sharing insights on sustainable tourism.