This proved to be a tense Champions League first match for head coach Thomas Frank, whose side battled to hold onto an surprise lead due to a shocking howler.
Tottenham enjoyed a perfect start when a Spurs attacker crossed a close-range ball into the area, which unbelievably rolled into the net after a mishandling by Villarreal's keeper Luiz Júnior.
The Spanish side fought for an tying goal throughout the match, with their winger showing himself to be a major menace down the wing.
Officiating decisions faced questioning, particularly when a Spurs defender challenged Georges Mikautadze on the verge of the area late in the game, only to get away with a booking.
The Ivorian subsequently sent the resulting set-piece narrowly off target, leaving Spurs to feel a massive sigh of thanks.
After the half-time, Tottenham seemed content to sit back their slender advantage, encouraging attacks from the Yellow Submarine.
Substitutions were made by both coaches, with Thomas Partey brought on to jeers from the Tottenham crowd.
Regardless of second-half attacks, Tottenham held on to secure a valuable three points in their European opener.
It was a evening defined by one moment and lots of tense moments for each teams.
This win marks a positive start to Tottenham's Champions League journey, even if questions linger about their readiness to excel at this level.
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